Born in Fredericton, New Brunswick, she was the daughter of George and Annie Parkin. She was educated in Canada, England and Switzerland. In 1914, she was appointed head of the women's students hostel at the University of Toronto. She married Vincent Massey the following year.
During Vincent Massey's term as High Commissioner for Canada in the United Kingdom, Alice became involved in organizations to assist Canadian service personnel in England during World War II, including a medical hospice for injured Canadian servicemen, the Canadian Officers' Club and the Montreal-based Beaver Club. Alice Massey also served as a member of the St. John Ambulance Brigade through World War II and would maintain her connection with St. John Ambulance until her death.
Massey died in Port Hope, Ontario on 29 July 1950, aged 71.